Data Science & Computational Biology
Isidro Cortes Ciriano

Welcome to

Isidro's personal website

About Computational Biology

Bombus sp. Isidro Cortes Ciriano

I am passionate about the human genome and its regulation, as well as drug discovery. My research lies at the interface of biology, artificial intelligence (machine learning), and statistics. During my PhD I integrated biological data sets (e.g. gene expression) and chemical properties of drug candidates in predictive models of compound activity. This approach permits to uncover new therapeutical targets and drugs, as well as to improve the current state of the art of virtual screening approaches. I am currently working on the analysis of next generation sequencing data (WES and WGS) from cancer patients and neurological diseases generated by The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Pan-Cancer Analysis of Whole Genomes (PCAWG), and Brain Somatic Mosaicism (BSM) Network.

About Data Science

The large amount of sequencing data generated from thousands of cell lines, non-neoplastic tissue and tumor samples over the last two decades is advancing our understanding of the non-coding genome and epigenome dramatically. These data are going to be crucial in the coming decades to understand the effect of genetic variants in disease and that of genomic alterations in cancer. It is the hope that the analysis of whole genome sequencing data will serve to find new drug targets and thus improve current pharmacological treatments. As a computational biologist I am deeply interested in finding new analytical techniques to leverage these data.

About ME

Isidro Cortes Ciriano erc

I am a postdoctoral researcher at the Park lab at the Department of Biomedical Informatics (Harvard Medical School). I am currenly funded by the European Commission, as I was awarded a Marie Skodowska-Curie Individual Global Fellowship (project PCFENCM) in February 2016 to work at the University of Harvard (Park lab) and the University of Cambridge (Bender lab). Previously, I did my PhD at the Structural Bioinformatics Unit (Institut Pasteur) as a fellow of the Pasteur-Paris International PhD Programme under the supervision of Dr. Therese Malliavin (Institut Pasteur) and Dr. Andreas Bender (University of Cambridge, UK). Prior to joining Pasteur, I received a Master's degree in Cell and Molecular Biology from the University of Zaragoza (Spain). I also hold a Licenciate (BSc + MSc) in Biological Sciences, a Licenciate in Biochemistry and a Diploma in Bioinformatics from the University of Navarra (Spain).